Treatment of Vasomotor Symptoms: From Hormone Therapy to Neurokinin Receptor Antagonists

Understanding the full spectrum of treatment options for menopausal vasomotor symptoms is essential for primary care physicians managing patients experiencing menopause. While menopausal hormone therapy remains the gold standard with 90-95% efficacy, many patients require alternative approaches due to contraindications or personal preferences.

In this interview, Lisa Larkin, MD, CEO and Founder of Ms.Medicine, provides a comprehensive overview of current treatment options for vasomotor symptoms. Dr Larkin discusses the effectiveness of hormone therapy compared to off-label antidepressant use, explains the science behind the new class of neurokinin receptor antagonists, and examines how recent advances in understanding the pathophysiology of hot flashes have led to more targeted therapeutic options. She also addresses the limitations and side effects of commonly prescribed treatments and what these newer medications offer patients who cannot or choose not to use hormone therapy.