Expert Perspectives 2024: Breakthrough Therapy for Congenital Adrenal Hyperplasia with PI Richard Auchus, MD, PhD

In this Patient Care© year-end video series we feature interviews with leading physician scientists and principal investigators who discuss the most important clinical trials of the year with experimental drugs, devices, and procedures, the implications of findings for daily primary care practice, and the promise of these unique additions to patient care.

Expert Perspectives 2024: Interviews with Key Opinion Leaders on Novel Therapeutics

In the interview series that begins with the video above, steroid biologist Richard Auchus, MD, PhD, discusses the pathophysiology of the rare genetic enzyme deficiency in the adrenal steroidogenic pathway, its physical and emotional impact on affected individuals and their families, the potentially dangerous adverse events associated with the standard of care – glucocorticoid replacement therapy – and the novel and newly approved corticotropin releasing factor-1 antagonist crinecerfont. In this first video, A Primer on Congenital Adrenal Hyperplasia with Expert Steroid Biologist Richard Auchus, MD, PhD, Auchus walks step-by-step through the etiology of CAH and the impact of the disease and the traditional treatment on patients.

Auchus is the James A. Shayman and Andrea S. Kevrick professor of translational medicine, professor of internal medicine, and professor of pharmacology at the University of Michigan Medical School in Ann Arbor, MI.

Following are links to all interviews in the series

The CAHtalyst Adult Phase 3 Clinical Trial of Crinecerfont: Principal Investigator Interview

More than 6 in 10 adults treated with the investigational CRF1 antagonist crinecerfont reached a physiologic glucocorticoid dose with androstenedione control maintained.

The Ideal Treatment for CAH? We Asked the Expert

Dr Richard Auchus says the ideal treatment for congenital adrenal hyperplasia is a long way off but describes a "block and replace" strategy that holds great promise.

Crinecerfont Could Help Improve Physical, Emotional Health for Individuals with CAH

Crinecerfont Could Help Improve Physical, Emotional Health for Individuals with CAH

A Primer on Congenital Adrenal Hyperplasia with Expert Steroid Biologist Richard Auchus, MD, PhD

Richard J Auchus, MD, PhD, a preeminent steroid biologist, provides a concise and thorough primer on CAH and the challenges in managing the disorder safely and effectively.