First AD

Second AD

A 42-year-old woman has gastroparesis which has responded well to metoclopromide. Given concerns over the side effects of metoclopramide, consideration is given to prescribing domperidone. 

Domperidone and metoclopromide are prokinetic agents which block dopamine receptors and stimulate gastric motility. The use of metoclopromide can be associated with serious side effects, specifically  tardive dyskinesia. Domperidone is generally better tolerated by patients; however, it can rarely be associated with prolongation of QT interval and lead to cardiac arrhythmias. Therefore, an ECG should be checked prior to initiation of this medication.

Gastroenterology

AIBD

Conference

Domperidone is better tolerated by some patients than metoclopramide. Before a switch, however, this test must be performed. 

Domperidone Rx for Gastroparesis: Which Test First?