Expert Interviews

Overview of Teplizumab for Delaying Onset and Progression of Type 1 Diabetes
January 20, 2025

Panelists discuss how teplizumab, the first FDA-approved disease-modifying therapy for Type 1 diabetes, can delay disease onset by targeting CD3+ T cells and preserving beta cell function in high-risk individuals.

Types of Antibody Screening Tests for Type 1 Diabetes
January 20, 2025

Panelists discuss how islet autoantibody testing serves as a critical screening tool for identifying Type 1 diabetes risk, with tests detecting antibodies against insulin, GAD65, IA-2, and ZnT8 proteins being the most clinically validated markers.

Patient Selection for Teplizumab and Infusion Process
January 20, 2025

Panelists discuss how patient selection for teplizumab therapy requires careful screening for autoantibody positivity and preserved C-peptide function, followed by a 14-day outpatient infusion process that needs close monitoring for cytokine release syndrome and other potential adverse effects.

Clinical Trial Data for Teplizumab
January 20, 2025

Panelists discuss how teplizumab demonstrated efficacy in clinical trials by delaying type 1 diabetes onset in high-risk patients.

Mechanism of Action of Teplizumab in Delaying Onset and Progression of Type 1
January 20, 2025

Panelists discuss how teplizumab binds to T cells and modifies their function to preserve beta cell function, potentially delaying type 1 diabetes onset in at-risk individuals by an average of 2-3 years.

Screening for Autoantibodies in Type 1 Diabetes
January 20, 2025

Panelists discuss how screening for autoantibodies can help identify individuals at risk for type 1 diabetes before symptoms develop, enabling earlier intervention and potentially delaying disease onset.

Hypertension Management in Patients with Obesity: 3 Pearls for Primary Care
January 17, 2025

Caissa Troutman, MD, shares 3 key strategies for managing hypertension in patients with obesity in primary care.

Screening Tools For OSA
January 17, 2025

Panelists discuss how validated questionnaires, clinical assessment tools, and overnight monitoring devices can help identify patients at risk for obstructive sleep apnea, though polysomnography remains the gold standard for definitive diagnosis.

Barriers To Diagnosing OSA
January 17, 2025

Panelists discuss how various obstacles impede obstructive sleep apnea diagnosis, including limited access to sleep studies, lack of patient awareness, high costs, long wait times for testing, and inconsistent screening practices among health care providers.

Obesity and Hypertension: Addressing Misconceptions in Clinical Practice
January 16, 2025

Caissa Troutman, MD, stresses the importance of building trust with patients through active listening and consistent, non-judgmental communication.