Renal Cancer

An 85-year-old man was admitted to the hospital with acough and shortness of breath of 1 week’s duration anda fever and increased sputum production for 2 days. Hishistory included renal cell carcinoma and metastatic renalcancer for 2 years. The patient had smoked cigarettesfor 30 years. He had lost 30 lb during the last few months.A chest film revealed pneumonia of the right lowerlobe. Metastatic nodules were noted on the scalp; extensivelung, bone, and brain metastases also were found.

A 40-year-old man was concerned about an enlarging painlessmass on the right side of his neck that had been presentfor 6 months (A). The patient reported no other healthproblems; his medical history was unremarkable, and hewas taking no medications.There was no family or personal history of thyroiddisease or of exposure to radiation. Thyroid function testresults were within normal limits. A chest film revealed nopathology.

A 43-year-old woman was admitted to the hospital withleft flank pain. The physical examination revealed a left abdominalmass. Laboratory test results identified normochromic-normocytic anemia (hematocrit, 33%; hemoglobin,10.8 g/dL; and mean corpuscular volume, 88 fL) andmicroscopic hematuria (10 red blood cells per high-powerfield).