Hepatology

 
Semaglutide 2.4 mg Approved for Treatment of MASH Without Cirrhosis: Daily Dose
August 26, 2025

Your daily dose of the clinical news you may have missed.

FDA Approves Semaglutide 2.4 mg for Treatment of MASH Without Cirrhosis
August 16, 2025

The accelerated approval for semaglutide 2.4 mg for the treatment of noncirrhotic MASH was based on part 1 of the phase 3 ESSENCE trial, which met its primary endpoints.

Investigational GPR119 Agonist Shows Dual Hepatoprotective and Glycemic Benefits in MASH Patients
May 07, 2025

EASL 2025. DA-1241 significantly reduced plasma ALT levels, improved systemic inflammatory and fibrosis biomarkers, according to drug developer MetaVia.

Viking Therapeutics Advances 3 Potential Obesity Treatments Based on Promising 2024 Clinical Trial Results
February 06, 2025

A GLP-1/GIP dual agonist in both subcutaneous and oral tablet formulations and a novel dual amylin and calcitonin receptor agonist lead the company's pipeline for antiobesity medications.

Bariatric Surgery Lowers Risk of Liver Complications in Patients with Cirrhosis, Obesity
January 28, 2025

Metabolic surgery reduced major adverse liver outcomes in people with compensated cirrhosis and obesity by 72%, according to new data.

The Liver Meeting 2024: Bausch Health Presents Phase 3 Study Design for Investigational Rifaximin Formulation to Delay OHE
November 19, 2024

The RED-C clinical trial program highlights the promising potential of the rifaximin soluble solid dispersion immediate-release tablets for delaying early HE-related decompensation.

Semaglutide 2.4 mg: Shows Superior Improvement in Liver Fibrosis, MASH Resolution in Pivotal Phase 3 Trial
November 04, 2024

Novo Nordisk announced the topline findings from the pivotal ESSENCE trial and intends to file applications in early 2025 with US and EU regulators.

Monotherapy with Rifaximin vs Lactulose More Effective for Reducing Recurrence of Overt Hepatic Encephalopathy: New Post Hoc Analysis
October 28, 2024

Rifaximin monotherapy may also confer a survival benefit, according to the study, which was awarded ACG Outstanding Research Award in the Liver Category.

Survodutide: Novel GCGR/GLP-1RA Shows Promise in Obesity, MASH Treatment
September 11, 2024

EASD 2024: New data shows survodutide may be beneficial for persons with obesity and MASH.

Tirzepatide Superior to Placebo in MASH Resolution, Fibrosis Improvement: Daily Dose
June 17, 2024

Your daily dose of the clinical news you may have missed.